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2,4,5-Trimethylanilin
(CAS-Nr.: 137-17-7)
und sein Hydrochlorid
(CAS-N r.: 21436-97-5)

Ausgabe: März 2001
Stand. November 2000

Preamble:

This document is mainly based on the criteria document of the German MAK Commission dating form 1993 [a] and the IARC Monograph [b]. All numerical citations refer to the citations in the document of the German MAK Commission [a].

2,4,5-trimethylaniline and its hydrochloride are inducers of methaemoglobinemia; they furthermore lead to damages in liver and lung. 2,4,5-trimethylaniline is a metabolite of the red dye Ponceau 3R [c].

Genotoxicity:

2,4,5-trimethylaniline has proved to be mutagenic in the Ames-Test after metabolic activation as well as in a wing spot test in Drosophila and in a mutation test on rat fibroblasts in culture (table 1). a DNa damaging activity of 2,4,5-trimethylaniline could be shown neither in V79 cells in vitro (table 1) nor in rat liver in vivo (table 2).

table 1: Results of genotoxicity tests in vitro

table 2: Results of genotoxicity tests in vivo

Carcinogenicity:

In chronic carcinogenicity studies on rats (CD, F 344) and mice (CD-1, B6C3F1) with application in the feed 2,4,5-trimethylaniline hydrochloride proved to be tumorigenic in both species. Localisations of the tumors are mainly the liver and to a lesser extent also the lung. The substance is hepatotoxic leading to liver hyperplasia and to neoplastic liver nodules.