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1-Ethoxypropan-2-ol
(CAS-NR.: 1569-02-4)
Ausgabe:
Mai 2002
Stand:
November 2001
Mutagenicity:
2PG1EE as well as the corresponding acetate (2PG1 EEA) were negative in an Amestest and in a cytogenetic assay in vitro on CHO cells Therefore, According to the EC classification criteria there is no classification warranted (M: -).
Carcinogenicity:
No data available. Therefore according to the EC classification criteria there is no classification possible (C: -).
Reproductive Toxicity/Fertility:
No specific test data available. In an inhalation assay on rats with 90 day exposure against max. 8,36 mg/l (6 h/d) there were no histopathological effects at the reproductive organs. Therefore according to the EC classification criteria there is no classification possible (RF: -).
Reproductive Toxicity/Development:
There are 2 teratology studies available with inhalative exposure of rats and rabbits. There were no foetal effects seen even in presence of maternal toxicity.
| Rat | 0.425; 1.913; 8.5 mg/l | 6 h/d, gd 6-15 | NOAEL/dams: 0.425 mg/l NOAEL/feti: 8.500 mg/l |
| Rabbit | 0.425; 1.489; 5.104 mg/l | 6 h/d, gd 6-18 | NOAEL/dams: 1.489 mg/l NOAEL/foetes: 5.104 mg/l |
Therefore according to the EC classification criteria there is no classification warranted (RE: -).
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