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Tabelle 7: Verursachungswahrscheinlichkeit in Prozent (gerundet) bei additiver Kombinationswirkung

BaP
Jahre
Asbestfaserjahr
012345678910111213141516171819202122232425
00471114171922242629313234363839404243444647484950
11581215172022252729313335363939414244454647484950
22691215182123252830323335373840414344454647484950
337101316192124262830323435373940424344454748495051
447111417192224262931323436383940424344464748495051
558121517202225272931333536383941424445464748495051
669121518212325283032333537384041434445464748495051
7710131619212426283032343537394042434445474849505152
8711141719222426293132343638394042434446474849505152
9812151720222527293133353638394142444546474849505152
10912151821232528303233353738404193444546474849505152
111013161921242628303234353739404243944547484950515253
121114171922242629313234363839404243444647484950515253
131215172022252729313335363839414244154647484950515253
141215182123252830323335373840414344454647484950515253
151316192124262830323435373940424344454748495051525353
161417192224262931323436373940424344464748495051525354
171517202225272931333536383941424445464748495051525354
181518212325283032333537384041434445464748495051525354
191619212426283032343537394042434445474849505152535354
201719222426293132343637394042434446474849505152535455
211720222527293133353638394142444546474849505152535455
221821232528303233353738404143444546474B49505152535455
231921242628303234353739404243414547484950515253535455
241922242629313234363739404243444647484950515253545555
252022252729313335363839414244454647484950515253545556
262123252830323335373840414344454647484950515253545556
272124262830323435373940424344454748495051525353545556
282224262931323436383940424344464748495051525354555556
292225272931333536383941424445464748495051525354555656
302325283032333537384041434445464748495051525354555657
312426283032343537394092434445474849505152535354555657
322426293132343638394042434446474849505152535455555657
332527293133353638394142444546474849505152535455565657
342528303233353738404143444546474849505152535455565757
352628303234353739404243444547484950515253535455565757
362629313234363739404243444647484950515253545555565758
372729313335363839414244454647484950515253545556565758
382830323335373840414344454647484950515253545556575758
392830323435373940424344454748495051525353545556575758
402931323436373940424344464748495051525354555556575858
412931333536383941424445464748495051525354555656575859
423032333537384041434445464748495051525354555657575859
433032343537394042434445474849505152535354555657575859
44313234363739404243444647484950515253545555'5657585859
4531333536383941424445.46474849505152535455565657585959
463233353738404143444546474849505152535455565757585959
473234353739404243444547484950515253535455565757585960
483234363839404243444647484950515253545555565758585960
493335363839414244454647484950515253545556565758595960
503335373840414344454647484950515253545556575758595960
513435373940424344454748495051525353545556575758596060
523436383940424344464748495051525354555556575858596060
533536383941424445464748495051525354555656575859596060
543537384041434445464748495051525354555657575859596061
553537394042434445474849505152535354555657575859606061
563638394042134446474849505152535455555657585859606061
57363839414244'4546474849505152535455565657585959606061
583738404143444546474849505152535455565757585959606161
593739404243444547484950515253535455565757585960606161
603839404243444647484950515253545555565758585960606162
613839414244454647484950515253545556565758595960606162
623840414344454647484950515253545556575758595960616162
633940424344454748495051525353545556575758596060616162
643940424344464748495051525354555556575858596060616262
653941424445464748495051525354555656575859596060616262
6640414344454647484950515253545556.57575859596061616262
674042434445474849505152535354555657575859606061616263
684042434446474849505152535455555657585859606061626263
694142449546474849505152535455565657585959606061626263
704143444546474819505152535455565757585959606161626263
714243444547484950515253535455565757585960606161626363
724243444647484950515253545555565758585960606162626363
734244454647484950515253545556565758595960606162626363
744344454647984950515253545556575758595960616162626364
754344454748495051525353545556575758596060616162636364
764344464748495051525354555556575858596060616262636364
774445464748495051525354555656575859596060616262636364
784445464748495051525354555657575859596061616262636464
794445474849505152535354555657575859606061616263636464
804446474849505152535455555657585859.606061626263636464
814546474849505152535455565657585959606061626263636464
824546474849505152535455565757585959606161626263646465
834547484950515253535455565757585960606161626363646465
844647484950515253545555565758585960606162626363646465
854647484950515253545556565758595960606162626363646465
864647484950515253545556575758595960616162626364646565
874748495051525353545556575758.5960606161626363646465.65
88474849505152535455555657585859606061626263'6364646565
894748495051525354555656575859596060616262636364646565
904748495051525354555657575859596061616262636464656566
914899505152535354555657575859606061616263636464656566
924849505152535455555657585859606061626263636464656566
934849505152535455565657585959606061626263636464656566
944849505152535455565757585959606161626263646465656666
954950515253535455565757585960606161626363646465656666
964950515253545555565758585960606162626363646465656666
974950515253515556565758595960606162626363646465656666
98495051525354555657'5758595960616162626364646565666666
995051525353545556575758596060616162636364646565666667
1005051525354555556575858596060616262636364646565666667

4 Literaturhinweise

Acheson, E.D., Gardner, M.J., Winter, P.D., Bennett, C.: Cancer in a factory using amosite asbestos. Int. J. Epidemiol. 13(1) (1984) 3-10

Ahlbohm, A., Alfredsson, L.: Interaction: A word with two meanings creates confusion. Europ. J. Epidemiol. 20 (2005) 563-564

Appel, K.E., Furstenberger, G., Hapke, H.J., Hecker, E., Hildebrandt, A.G., Koransky, W., Marks, F., Neumann, H.G., Ohnesorge, F.K., Schulte-Hermann, R.: Chemical cancerogenesis: definitions of frequently used terms. J. Cancer Res. Clin. Oncol. 116(3) (1990) 232-236

A.rmstrong, B., Tremblay, C., Baris, D., Theriault, G.: Lung cancer mortality and polynueclear aromatic hydrocarbons: a casecohort study of aluminium production workers in Arvida, Quebec, Canada. Am. J. Epid. 139 (1994) 250-262

Ault, J.G., Cole, R.W., Jensen, C.G., Jensen, L.C., Bachert, L.A., Rieder, C.L.: Behavior of crocidolite asbestos during mitosis in living vertebrate lang epithelial cells. Cancer Res. 55(4) (1995) 792-798

Baird, W.M., Hooven, L.A., Mahadevan, B.: Carcinogenic polycyclic aromatic hydrocarbon-DNA adducts and mechanism of action. Environ. Mol. Mutagen. 45(2-3) (2005) 106-14

Baker, E.L., Dagg, T., Greene, R.E.: Respiratory illness in the construction trades. I. The significance of asbestosassociated pleural disease among sheet metal workers. J. Occup. Med. 27(7) (1985) 483-489

Bakke, P., Eide, G.E., Hanoa, R., Gulsvik, A.: Occupational dust or gas exposure and prevalence of respiratory symptoms and asthma in a general Population. Eur. Respir. J. 4 (1991) 273-278

Barrett, J.C., Lamp, P.W., Wiseman, R.W.: Multiple mechanisms for the carcinogenic effects of asbestos and other mineral fibers. Environ. Health Perspect. 81 (1989) 81-89

Bernstein, D., Castranova, V., Donaldson, K., Fubini, B., Hadley, J., Hesterberg, T, Kane, A., Lai, D., McConnell, E.E., Muhle, H., Oberdorster, G., C)lin, S., Warheit, D.B.: Testing of fibrous particles: Shortterm assay and strategies. Report of an ILSI Risk Science Institute Working Group. Inhal. Toxicol. 17 (2005) 497-537

Berger, M.R.: Synergism and antagonism between chemical carcinogens. In: Arcos, J.C., Argns, M.F., Woo, Y.: Chemical induction of cancer: Modelation and combination effects. An inventory of the many factors which influence carcinogenesis, Baston, Birkhänser, 1996

Berry, G., Newhouse, M.L., Turok, M.: Combined effects of asbestos exposure and smoking on mortality from lung cancer in factory workers. Lancet 2 (1972) 476-479

Berry, G., Newhouse, M.L., Antonis, P.: Combined effects of asbestos and smoking on mortality from lung cancer and mesothelioma in factory workers. Br. J. Ind. Med. 42 (1985) 12-18

BeruBe, K.A., Quinlan, T.R., Moulton, G., Hemenway, D., O'Shaughnessy, P., Vacek, P., Mossman, B.T.: Comparative proliferative and histopathologic changes in rat lung after inhalation of chrysotile and crocidolite asbestos. Toxicol. Appl. Pharmacol. 137 (1996) 67-74

Blot, W.J., Harrington, J.M., Toledo, A., Hoover, R., Heath, C.W. Jr., Fraumeni, J.F. Jr.: Lung cancer after employment in shipyards during World War II. N. Engl. J. Med. 299(12) (1978) 620-624

Blot, W.J., Morris, L.E., Stroube, R., Tagnon, I., Fraumeni, J.R. Jr.: Lung and laryngeal cancers in relation to shipyard employment in coastal Virginia. J. Natl. Cancer Inst. 65(3) (1980) 571-575

Bundesministerium für Arbeit und Sozialordnung (Hrsg.): Lungenkrebs durch polyzyklische aromatische Kohlenwasserstoffe beim Nachweis der Einwirkung einer kumulativen Dosis von mindestens 100 Benzo[a]pyren-Jahren ) x Jahre]. Empfehlung des Arztlichen Sachverständigenbeirats, Sektion "Berufskrankheiten". BArbB1 4 (1998) 54-61

Boffetta, P.: Health effects of asbestos exposure in humans. A quantitative assessment. Med. Lav. 89 (6) (1998) 471-480

Bolm-Audorf, U.: Polyzyklische aromatische Kohlenwasserstoffe. In: K.onietzko, Dupuis (Hrsg.): Handbuch der Arbeitsmedizin 21(11) (1998) 1-31

Both, K., Henderson, D.W., Turner, D.R.: Asbestos and erionite fibres can induce mutations in human lymphocytes that result in loss of beterozygosity. Int. J. Cancer 59(4) (1994) 538-542

Boylan, A.M., Sana, D.A., Sheppard, D., Broaddus, V.C.: Vitronectin enhances internalization of crocidolite asbestos by rabbit pleural mesothelial cells via the integrin ävä5. J. Clin. Invest. 96 (1995) 1987-2001

Broaddus, V.C., Yang, L., Scavo, L.M., Ernst, J.D., Boylan, A.M.: Asbestos induces apoptosis of human and rabbit pleural mesothelial cells via reactive oxygen species. J. Clin. Invest. 98 (1996) 2050-2059

Brody, A.R., Liu, J.Y., Brass, D., Corti, M.: Analyzing the genes and peptide growth factors in lung cells in vivo consequent to asbestos exposure and in vitro. Environ. Health Perspect. 105 (1997) Suppl. 5, 1165-1171

Brüske-Hohlfeld, I., Möhner, M., Wichmann, H.-E.: Lungenkrebsrisiko von Uranbergleuten der Wismut-AG durch die berufliche Strahlenexposition in Kombination mit Asbest - ein Konzept der Verursachungswahrscheinlichkeit multifaktoriell bedingter Erkrankungen. 38. Jahrestagung der DGAUM, Wiesbaden, Rindt, Fulda, 1998, 138 - 142

Carbone, M., Rizzo, P., Grimley, P.M., Procopio, A., Mew, D.J., Shridhar, V., de Bartolomeis, A., Esposito, V., Giuliano, M.T., Steinberg, S.M., Le vine, A.S., Giordano, A., Pass, H.I.: Simian virus-40 large-T antigen binds p53 in human mesotheliomas. Nat. Med. 3(8) (1997) 908-912

Chao, C.C., Park, S.H., Aust, A.E.: Participation of nitric oxide and fron in the oxidation of DNA in asbestostreated human lung cells. Arch. Biochem. Biophys. 326 (1996) 152-157

Cheng, W.N., Kong, J.: A retrospective mortality cohort study of chrysotile asbestos products workers in Tianjin 1972-1987. Environ. Res. 59(1) (1992) 271-278

Cole, R.W., Ault, J.G., Hayden, J.H., Rieder, C.L.: Crocidolite asbestos fibres undergo sizedependent microtubulemediated transport after endocytosis in vertebrate lung epithelial cells. Cancer Res. 51(18) (1991) 4942-4947

Constantino, J.P., Redmond, C.K., Bearden, A.: Occupationally related cancer risk among coke oven workers: 30 years of followup. J. Occup. Environ. Med. 37 (1995) 597-604

Dement, J.M., Brown, D.P.: Lung cancer mortality among asbestos textile workers: a review and update. Ann. Occup. Hyg. 38 (1994) 525-532

Dement, J.M., Harris, R.L., Symons, M.J., Shy, C.: Exposure and mortality among chrysotile asbestos workers, Part II: Mortality. Am. J. Ind. Med. 4 (1983) 421-433

Dement, J.M., Harris, R.L., Symons, M.J., Shy, C.: Estimates of doseresponse for respiratory cancer among chrysotile asbestos textile workers. Ann. Occup. Hyg. 26(1-4) (1982) 869-887

Deutsch-Wenzel, R.P., Brune, H., Grimmer, G., Dettbarn, G., Misfeld, J.: Experimental studies in rat lungs on the carcinogenicity and doseresponse relationship of eight frequently occurring environmental polycyclic aromatic hydrocarbons. JNCI 71 (1983) 539-544

Donaldson, K.: Shortterm animal studies for detektion inflammation, fibrosis and preneoplastic changes indced by fibros. In: Kane, A.B., Bofetta, P., Saracci, R., Wilbourn, J.D. (eds.): Mechanisms of fibre carcinogenesis. IARC Scientific Publication No. 140, Lyon, 1996, 97-106

Dopp, E., Saedler, J., Stopper, H., Weiss, D.G., Schiffmann, D.: Mitotic disturbances and micronucleus induction in Syrian hamster embryo fibroblast cells caused by asbestos fibres. Environ. Health Perspect. 103(3) (1995) 268-271

Driscoll, K.E., Deyo, L.C., Carter, J.M., Howard, B.W., Hassenbein, D.G., Bertram, T.A.: Effects of particle exposure and particleelicited inflammatory cells on mutation in rat alveolar epithelial cells. Carcinogenesis 18 (1997) 423-430]

Druckrey, H., Schildbach, A., Schmähl, D., Preussmann, R., Ivankovic, S.: Quantitative Analyse der carcinogenen Wirkung von Diäthyl-nitrosamin. Zeitschrift für Arzneim. Forsch. 13 (1963) 841-851

Durnev, A.D., Daugel-Dauge, N.O., Korkina, L.G., Seredenin, S.B.: Peculiarities of the clastogenic properties of chrysotileasbestos fibers and zeolite particles. Mutat. Res. 319(4) (1993) 303-308

Etz, P., Woitowitz, H.-J.: Die Bedeutung synkanzerogener Bronchialkarzinom-Risiken am Arbeitsplatz - Ergebnisse einer Fallsammlung. In: Verhandlungsbericht der Dtsch. Ges. f. Arbeitsmed. e.V. 28. Jahrestagung, Innsbruck 1988. Stuttgart, Gentner, 1988, 573-575

Evanoff, B.A., Gustavsson, P., Hogstedt, C.: Mortality and incidence of cancer in a cohort of Swedish chimnrey sweeps: an extended follow up study. Brit. J. Ind. Med. 50 (1993) 450-459

Fatma, N., Jain, A.K., Rahman, Q.: Frequency of sister chromatid exchange and chromosomal aberrations in asbestos cement workers. Br. J. Ind. Med. 48(2) (1991) 103-105

Finkelstein, M.M.: Mortality among long term employees of an Ontaria asbestoscement factory. Br. J. Ind. Med. 40 (1983) 138-144

Fung, H., Kow, Y.W., Van Houten, B., Mossman, B.T.: Patterns of 8-hydroxydeoxyguanosine formation in DNA and indications of oxidative stress in rat and human pleural mesothelial cells after exposure to crocidolite asbestos. Carcinogenesis 18 (1997) 825-832

Gannon, P.F., Burge, P.S.: The SHIELD scheme in the West Midlands Region, United Kingdom. Br. J. Ind. Med. 50 (1993) 791-796

Gibbs, G.W., Baron, P., Beckett, S.T., Dillen, R., du Toit, R.S., Koponen, M., Robock, K.A.: Summary of asbestos fibre counting experience in seven countries. Ann. Occup. Hyg. 20 (4) (1977) 321-332

Gibbs, G.W.: Mortality of aluminium reduction plant workers. 1950 through 1977. J. Occup. Med. 27 (1985) 761-770

Goldberg, J.L., Zanella, C.L., Janssen, Y.M.W., Timblin, C.R., Jimenez, L.A., Vacek, P., Taatjes, D.J., Mossman, B.T.: Novel cell imaging techniques show induction of apoptosis and proliferation in mesothelial cells by asbestos. Am. J. Respir. Cell. Mol. Biol. 17 (1997) 265-271

Greim, H., ed. Gesundheitsschädliche Arbeitsstoffe.Toxikologischarbeitsmedizinische Begründung von MAK-Werten. (Loseblattsammlung). Weinheim, WILEY-VCH ab 1972 (DFG-Publikation)

Greim, H., Borm, P., Schins, R., Donaldson, K., Driscoll, K., Hartwig, A., Kuempel, E., Oberdorster, G., Speit, G.: Toxicity of fibers and particles. Report of the workshop held in Munich, Germany 26-27 October 2000. Inhal. Toxicol. 13 (2001) 737-754

Greim, H.: Synkanzerogenese - eine Übersicht zum wissenschaftlichen Erkenntnisstand. Fachgespräch zur Synkanzerogenese. Berufsgenossenschaftliche Akademie, Hennef 26.11.2005

Grimmer, G., Brune, H., Deutsch-Wenzel, R., Dettbarn, G., Misfeld, J., Abel, U., Timm, J.: The contribution of polycyclic aromatic hydrocarbons to the carcinogenic impact of emission condensate from coalfired residential furnaces evaluated by topical applicatiön to the skin of mice. Cancer Let. 23 (1984) 167-176

Grimmer, G., Brune, H., Deutsch-Wenzel, R., Dettbarn, G., Jacob, J., Naujack, K.W., Mohr, U., Ernst, H.: Contribution of polycyclic aromatic hydrocarbons and polar polycyclic aromatic compounds to the carcinogenic impact of flue gas condensate from coalfired residential furnaces evaluuated by implantation into the rat lung. J. Nat. Cancer Inst. 78 (1987a) 935-942

Gustavsson, P., Alhbom, A., Anderson, T., Scheele, P.: Calculation of fractions of lung cancer incidence attributable to occupational exposure to asbestos and combustion products in Stockholm, Sweden. Eur. J. Epidemiol. 18 (2003) 937-940

Haguenoer, J.M., Shirali, P., Hannothiaux, M.H., Nisse-Ramond, C.: Interactive effects of polycyclic aromatic hydrocarbons and iron oxides particles. Epidemiological and fundamental aspects. Cent. Eur. J. Public Health 4 (1996) Suppl, 41-5.

Hallier, E.: Synkanzerogenese - Wechselwirkungen zwischen krebserzeugenden Noxen am Arbeitsplatz. Kommunique der Deutschen Gesellschaft für Arbeitsmedizin und Umweltmedizin e.V. Zentralblatt Arbeitsmedizin 54 (2004) 147-149

Hammond, E.D., Selikoff, I.J., Seidman, H.: Asbestos exposure, cigarette smoking and death rates. Ann. N. Y. Acad. Sci. 330 (1979) 473-490

Hanahan, D., Weinberg, R.A.: The hallmarks of cancer. Cell 100 (2000) 57-70

Hardy, J.A., Aust, A.E.: Iron in asbestos chemistry and carcinogenicity. Chem. Rev. 95 (1995a) 97-118

Hardy, J.A., Aust, A.E.: The effect of iron binding on the ability of crocidolite asbestos to catalyse DNA singlestrand breaks. Carcinogenesis 16(2) (1995b) 319-325

Harns, C.C., Bennett, W.P., Gerwin, B.I., Iman, D.S., Lehmann, T.A., Metcalf, R.A., Pfeiffer, A.M.A., Reddel, R.R., Sugimura, H., Weston, A.: Oncogenes and tumor suppressor genes involved in human lung carcinogenesis. In: Brugge, J., Curran, T., Harlow, E.D., McCormick (Hrsg.): Origins of human cancer. A comprehensive review. New York, Gold Spring Harbor Laboratory Press, 1991, 739,-744

Hayes, A.W.: Principles and methods of toxicology. Philadelphia, Taylor & Francis, 2001, 990

Hei, T.K., Piao .Q., He, Z.Y., Vannais, D., Waldren, C.A.: Chrysotile fiber is a strong mutagen in mammalian cells. Cancer Res. 52(22) (1992) 6305-6309

Hei, T.K., He, Z.Y., Suzuki, K.: Effects of antioxidants on fiber mutagenesis. Carcinogenesis 16 (1995) 1573-1578

Hei, T.K., Xu, A., Louie, D., Zhao, Y.L.: Genotoxicity versus carcinogenicity; implications from fiber toxicity studies. Inhal. Toxicol. 12 (2000) Suppl. 3, 141-147

Heinrich, U.: Erkenntnisse zur Aussagefähigkeit von Tierversuchen und Invitro-Versuchen zu Kombinationswirkungen, insbesondere zum Zusammenhang PAK und Asbest. Fachgespräch zur Synkanzerogenese. Berufsgenossenschaftliche Akademie, Hennef 26.11.2005

Heinrich, U., Fuhst, R., Peters, L., Muhle, H., Dasenbrock, C., Pott, F.: Comparative longterm animal inhalation studies using various particulate matter: objectives, experimental design and preliminary results. Exp. Pathol. 37 (1989) 27-31

Heinrich, U., Pott, F., Rittinghausen, S.: Comparison of chronic inhalation effects in rodents after long term exposure to either coal oven flue gas mixed with pyrolized pitch of Diesel engine exhaust. In: Ishinishi, N. (ed.): Carcinogenic and mutagenic effects of Diesel engine exhaust. Developments in Toxicology and Environmental Science. Amsterdam, New York, Oxford Sci. Publ. 13 (1986) 441-457

Heinrich, U., Roller, M., Pott, F.: Estimation of a lifetime unit lung cancer risk for benzol[a]pyrene (BaP) based on tumour rates in rats exposed to coal tar/pitch condensation (CTP) aerosol. Toxicol. Letters 72 (1994) 155-161

Henschler, D.: Arbeitsbedingte Synkanzerogenese bei KI-Stoffen aus toxikologischer Sicht. Workshop der Deutschen Gesellschaft für Arbeitsmedizin und Umweltmedizin, 25./26.02.2004 in Berlin, Fachgespräch des HVBG und der DGAUM am 25./26.11.2005 in Hennef, BK-Report 2/2006. In: HVBG (Hrsg.): Synkanzerogenese - insbesondere Asbeststaub und PAK; Plump OHG, Rheinbreitbach, ISBN 388.383-707-5 (2006) 289-296

Hesterberg, T.W., Barrett, J.C.: Induction by asbestos fibers of anaphase abnormalities: mechanism for aneuploidy induction and possibly carcinogenesis. Carcinogenesis 6(3) (1985) 473-475

Hilt, B., Langard, S., Andersen, A., Rosenberg, J.: Asbestos exposure, smoking habits, and cancer incidence among production and maintenance workers in an electrochemical plant. Am. J. Ind. Med. 8(6) (1985) 565-577

Horikawa, K., Sera, N., Otofuji, T., Murakami, K., Tokiwa, H., Iwagawa, M., Izumi, K., Otsuka, H.: Pulmonary carcinogenicity of 3,9- and 3,7-Dinitrofluoranthene, 3-Nitrofluoranthene and Benzol[a]pyrene in F344 rats. Carcinogenesis 12 (1991) 1003-1007

IARC. Polynuclear aromatic compounds, Part 1. Chemical, environmental and experimental data. Summary of data reported and evaluation. IARC Monogr. Eval. Carcinogen. Risks Hum. 32 (1983) 1-477

IARC. Polynuclear aromatic compounds, Part 3. Industrial exposures in aluminium production, coal gasification, coke production, and iron and steel founding. Summary of data reported and evaluation. IARC Monogr. Eval. Carcinogen. Risks Hum. 34 (1984) 1-219

IARC. Asbestos. IARC Monogr. Eval. Carcinogen. Risks Hum. (1987) Suppl. 7, 106-116

IARC. Silica, some silicates, coal dust and paraaramid fibris. IARC Monogr. Eval. Carcinogen. Risks Hum. 68 (1997) 1-506

IARC. Surgical implants and other foreign bodies. IARC Monogr. Eval. Carcinogen. Risks Hum. 74 (1999) 313-317

IARC. Manmade vitreous fibres. IARC Monogr. Eval. Carcinogen. Risks Hum. 81 (2002) 43-80, 339.

ILSI. Testing of fibrous particles: shortterm assays and strategies. Report of an ILSI Risk Science Institute Working Group. Inhal. Toxicol. 17 (2005) 1-41

Iwagawa, M., Maeda, T., Izumi, K., Otsuka, H., Nishfuji, K., Ohnishi, Y, Aoki, S.: Comparenntive doseresponse study on the pulmonary carcinogenicity of 1,6-Dinitropyrene and Benzo[a]pyrene in F344 rats. Carcinogenesis 10 (1989) 1285-1290

Jaurand, M.C., Kheunang, L., Magne, L., Bignon, J.: Chromosomal changes induced by chrysotile fibres or benzo-3,4-pyrene in rat pleural mesothelial cells. Mutat. Res. 169(3) (1986) 141-148

Jaurand, M.C.: Use of invitro genotoxicity and cell transformation assays to evaluate the potential carcinogenicity of fibers. In: Kane, A.B., Bofetta, P., Saracci, R., Wilbourn, J.D. (eds.): Mechanisms of fibre carcinogenesis. IARC Scientific Publication No. 140, Lyon, 1996, 55-72

Jensen, C.G., Jensen, L.C., Rieder, C.L., Cole, R.W., Ault, J.G.: Long crocidolite asbestos fibers cause polyploidy by sterically blocking cytokinesis. Carcinogenesis 17(9) (1996) 2013-2021

Jöckel, K.-H., Ahrens, W., Jahn, I., Pohlabeln, H., Bolm-Audorff, U.: Untersuchungen zu Lungenkrebs und Risiken am Arbeitsplatz. Schriftenreihe der Bundesanstalt für Arbeitsmedizin, Bremerhaven, Wirtschaftsverlag NW11.995

Jung, M., Davis, W.P., Taatjes, D.J., Churg, A., Mossman, B.T.: Asbestos and cigarette smoke cause increased DNA strand breaks and necrosis in bronchiolar epithelial cells in vivo. Free Radical. Biol. Med. 28 (2000) 1295-1299

Kane, A.B.: Mechanisms of mineral fibre carcinogenesis. In: Kane, A.B., Boffetta, P., Saracci, R., Wilbourn, J.D. (eds.): Mechanisms of fibre carcinogenesis. IARC Scientific Publication No. 140, Lyon, 1996, 11-34

Kane, A.B., Macdonald, J.L., Vaslet, C.A.: Regulation of mesothelial cell proliferation in vitro and in vivo. In: Vitro and In Vivo Investigations in Inhalation Toxicology, Washington DC, ILSI Press, 1997, 163-171

Kimizuka, G., Wang, N.S., Hayashi, Y.: Physical and microchemical alterations of chrysotile and amosite asbestose in the hamster lung. J. Toxicol. Environ. Health 21 (1987) 251-264

Kjuus, H., Skjaerven, R., Lang-*rd, S., Lien, J.T., Aamodt, T.: A casereferent study of lung cancer, occupational exposures and smoking. I Comparison of titlebased and exposurebased occupational information. Scand. J. Work Environ. Health 12 (1986) 193-202

Kjuus, H., Skjaerven, R., Langrd, S., Lien, J.T., Aamodt, T.: A casereferent study of lung cancer, occupational exposures and smoking. Il Role of asbestos exposure. Scand. J. Work Environ. Health 12 (1986) 203-209

Kjuus, H., Lang-+rd, S., Skjaerven, R., Lien, J.T., Aamodt, T.: A casereferent study of lung cancer, occupational exposures and smoking. III Etiologic fraction of occupational exposures. Scand. J. Work Environ. Health 12 (1986) 210-215

De Klerk, N.H., Musk, A.W., Armstrong, B.K., Hobbs, M.S.: Smoking, exposure to crocidolite, and the incidence of lung cancer and asbestosis. Br. J. Ind. Med. 48(6) (1991) 412-417.

Kodama, Y., Boreiko, C.J., Maness, S.C., Hesterberg, T.W.: Cytotoxic and cytogenetic effects of asbestos on human bronchial epithelial cells in culture. Carcinogenesis 14(4) (1993) 691-697

Leanderson, P., Soderkvist, P., Tagesson, C., Axelson, O.: Formation of DNA adduct 8-hydroxy-2'-deoxyguanosine induced by manmade mineral fibres. In: Bartsch, H., Hemminki, K., IKO'Neil (eds.): Methods for detecting DNA damaging agents in humans: Applications in cancer epidemiology and prevention. IARC Sci. Publ. 89 (1988) 422-424

Leanderson, P., Tagesson, C.: Rapid nand sensitive detection hydroxyl radicals formed by activated neutrophils in the presence of chelated iron: hydroxylation of deoxyguanosine to 8-hydroxydeoxyguanosine. Agents Actionbs. 36(1-2) (1992) 50-57

Lee, B.W., Wain, J.C., Kelsey, K.T., Christiani, D.C.: Association of cigarette smoking and asbestos exposure with location and histology of lung cancer. Am. J. Respir. Crit. Care Med. 157 (1998) 748-755

Levresse, V., Renier, A., Fleury-Feith, J., Levy, F., Moritz, S., Vivo, C., Pilatte, Y., Jaurand, M.C.: Analysis of cell cycle disruptions in cultures of rat pleural mesothelial cells exposed to asbestos fibers. Am. J. Respir. Cell. Mol. Biol. 17 (1997) 660-671

Levresse, V., Renier, A., Levy, F., Broaddus, V.C., Janrand, M.: DNA breakage in asbestostreated normal and transformed (TSV40)rat pleural mesotheline cells. Mutagenesis 15(3) (2000) 239-244

Liddell, F.D., Thomas, D.C., Gibbs, G.W.; McDonald, J.C.: Fibre exposure and mortality from pneumoconiosis, respiratory, and abdominal malignancies in chrysotile production in Quebec, 1926-1975. Ann. Acad. Med. Singap. 13 (1984) Suppl. 2, 340-344

Liu, J.Y., Morris, G.F., Lei, W.H., Corti, M., Brody, A.R.: Upregulated expression of transforming growth factor-ä in the bronchiplaralveolar duct regions of asbestosexposed rats. Am. J. Pathol. 149 (1996) 205-217

Liu, W., Ernst, J.D., Broaddus, V.C.: Phagocytosis of crocidolite asbestos induces oxidative stress, DANN damage, and apoptosis in meseothelial cells. Am. J. Respir. Cell. Mol. Biol. 3 (2000) 371-378

Loli, P., Topinka, J., Georgiadis, P., Duinska, M., Hurbänkova, M., Koväeikova, Z., Volkovovä K., Wolff, T., Oesterle, D., Krytopoulos, S.A.: Benzo[a]pyreneenhanced mutagenesis by asbestos in the lung of X-lacI transgenic rats. Mutat. Res. 5.33 (2004) 79-90

Luster, M.I., Simeonova, P.P.: Asbestos induces inflammatory cytokines in the lung through redox sensitive transcription factors. Toxicol. Letters 28 (1998) 102-103, 271-275

Manning, C.B., Vallyathan, V., Mossman, B.T.: Disease caused by asbestos: Mechanisms of injury and disease development. Int. Immunopharmacol. 2 (2002) 191-200

Martischnig, K.M., Newell, D.J., Barnsley, W.C., Cowan, W.K., Feinmann, E.L., Oliver, E.: Unsuspected exposure to asbestos and bronchogenic carcinoma. Br. Med. J. 1(6063) (1977) 746-749

Marczynski, B., Czuppon, A.B., Marek, W., Reichel, G., Baur, X.: Increased incidence of DNA doublestrand breaks and antids DNA antibodies in blood of workers occupationally exposed to asbestos. Hum. Exp. Toxicol. 13 (1) (1994) 3-9

Mazumdar, S., Redmond, C., Sollecito, W., Sussman, N.: An epidemiological study of expurse to coal tat pitch volatiles among coke oven workers. J. Air Poll. Contr. Ass. 25 (1975) 382-389

McDonald, A.D., Fry, J.S., Woolley, A.J., McDonald, J.C.: Dust exposure and mortality in an American chrysotile textile plant. Br. J. Int. Med. 40 (1983) 361-367

Mossman, B.T., Kamp, D.W., Weitzman, S.A.: Mechanisms of carcinogenesis and clinical features of asbestosassociated cancers. Cancer Invest. 14(5) (1996) 466-480

Mossman, B.T., Faux, S., Janssen, Y., Jimenez, L.A., Timblin, C., Zanella, C., Goldberg, J., Walsh,

E., Barchowsky, A., Driscoll, K.: Gell signalling pathways elicited by asbestos. Environ. Health Perspect. 105 (1997) Suppl. 5, 1121-1125

Muhle, H., Pott, F.: Asbestos as reference material for fibreinduced cancer. Int. Arch. Occu. Environ. Health 73 (2000) Suppl. S53-S59

Nelson, H.H., Kelsey, K.T.: The molecular epidemiology of asbestos and tobacco in lung cancer. Oncogene 21 (2002) 7284-7288

Okayasu, R., Wu, L., Hei, T.K.: Biological effects of naturally occurring and manmade fibres: in vitro cytotoxicity and mutagenesis in mammalian cells. Br. J. Cancer 79(9/10) (1999) 1319-1324


Pache, J.C., Janssen, Y.M., Walsh, E.S., Quinlan, T.R., Zanella, C.L., Low, K.B., Taatjes, D.J., Mossman, B.T.: Increased epidermal growth factorreceptor protein in a human mesothelial cell line in response to long asbestos fibers. Am. J. Pathol. 152 (1998) 333-340


Palekar, L.D., Eyre, J.F., Most, B.M., Coffin, D.L.: Metaphase and anaphase analysis of V79 cells exposed to erionite, UICC chrysotile and UICC crocidolite. Carcinogenesis 8(4) (1987) 553-560


Park, S.H., Aust, A.E.: Participation of iron and nitric oxide in the mutagenicity of asbestos in hgprt gpr+ Chinese hamster. V79 cells. Cancer Res. 58 (1998) 1144-1148


Pastorino, U., Berrino, F., Gervasio, A., Pesenti, V., Riboli, E., Crosignani, P.: Proportion of lung cancers due to occupational exposure. Int. J. Cancer 33(2) (1984) 231-237


Peto, J.: Lung cancer mortality in relation to measured dust levels in an asbestos textile factory. In: Wagner, J.C., Davis, W. (eds): Biological effects of mineral fibers. IARC, Lyon: 2(30) (1980) 829-836


Peto, R., Gray, R., Brantom, P., Grasso, P.: Dose and time relationships for tumor induction in the liver and esophagus of 4080 inbred rats by chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine. Cancer Res. 51 (1991a) 6452-69


Peto, R., Gray, R., Brantom, P., Grasso, P.: Effects an 4080 rats of chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine: a detailed doseresponse study. Cancer Res. 51 (1991b) 6415-51


Pohlabeln, H., Wild, P., Schill, W., Ahrens, W., Jahn, I., Bolm-Audorff, U., Jöckel, K.H.: Asbestos fibreyears and lung cancer: a two phase casecontrol study with expert exposure assessment. Occup. Environ. Med. 59 (2002) 410-414


Popp, W., Norpoth, K.: Aktuelle Erkenntnisse zur Synkanzerogenese. In: 12. Duisburger Gutachtenkolloquium, 1995. Arbeitsmedizinischer Teil. Landesverband Rheinland-Westfalen der gewerblichen Berufsgenossenschaften (eds.), Düsseldorf 1996, 23-67


Pott, F., Heinrich, U.: Staub und Staubinhaltsstoffe/Polyzyklinische aromatische Kohlenwasserstoffe (PAK). In: Wichmann, H.J., Schlipköter, H.W., Fülgraff, G. (Hrsg.): Handbuch für Umweltmedizin, Landsberg/Lech, Ecomed-Verlag, Loseblattsammlung, 1. Lieferung, 1990

Reinisch, F., Harrison, R.J., Cussler, S., Athanasoulis, M., Balmes, J., Blanc, P., Cone, J.: Physician reports of workrelated asthma in California, 1993-1996. Am. J. Ind. Med. 39 (2001) 72-83

Rihn, B., Coulais, C., Kauffer, E., Bottin, M.-C., Martin, P., Yvon, F., Vigheron, J.C., Binet, S., Monhoven, N., Steiblen, G., Keith, G.: Inhaled crocidolite mutagenicity in lung DNA. Environ. Health Perspect. 108 (2000) 341-346

Rihn, B.H., Mohr, S., McDowell, S.A., Binet, S., Loubinoux, J., Galateau, F., Keith, G., Leikauf, G.D.: Differential gene expression in mesothelioma. FEBS Letters 480 (2000) 95-100

Robledo, R.F., Buder-Hoffmann, S.A., Cummins, A.B., Walsh, E.S., Taatjes, D.J., Mossmann, B.T.: Increased phosphorylated extracellular signalregulated kinase immunoreactivity associated with proliferative and morphologic lung alterations after chrysotile asbestos inhalation in mice. Am. J. Pathol. 156 (2000) 1307-1316

Rösler, J.A., Woitowitz, H.-J., Lange, H.-J., Ulm, K., Woitowitz, R.H., Rödelsperger, K.: Asbesteinwirkung am Arbeitsplatz und Sterblichkeit an bösartigen Tumoren in der Bundesrepublik Deutschland. Forschungsbericht Asbest IV. Hauptverband der gewerblichen Berufsgenossenschaften (HVBG). Schriftenreihe des Hauptverbandes der gewerblichen Berufsgenossenschaften, Sankt Augustin: HVBG, 1993

Rom, W.N., Livingston, G.K., Casey, K.R., Wood, S.D., Egger, M.J., Chiu, G.L., Jerominski, L.: Sister chromatid exchange frequency in asbestos workers. J. Natl. Cancer Inst. 70(1) (1983) 45-48

Rosenthal, G.J., Germolee, D.R., Blazka, M.E., Corsini, E., Simeonova, P., Pollock, P., Kong LYon, J., Luster, M.I.: Asbestosos stimulates IL-8 production lung epithelial cells. J. Immunol. 153 (1994) 3237-3244

Rubin, H.: Synergistic mechanisms in carcinogenesis by polycyclic aromatic hydrocarbons and by tobacco smoke: a biohistorical perspective with updaes. Carcinogenesis 12 (2001) 1903-1930

Sahu, A.P.: Effect of choline and mineral fibres (chrysotile asbestos) an guineapigs. IARC Sci. Publ. 90 (1989) 185-189

Sakabe, H., Kenzaburo, T., Nobolru, T., Shigeru, N., Shigezi, K., Kazuo, T., Hidetsury, M., Yukio, M.: Lung cancer among coke oven workers. A Report to Labour Standard Bureau, Ministry of Labour, Japan. Ind. Health 13 (1975) 57-68

Sandhu, H., Dehnen, W., Roller, M., Abel, J., Unfried, K.: mRNA expression patterns in different stages of asbestosinduced carcinogenesis in rats. Carcinogenesis 21 (2000) 1023-1029

Saracci, R., Boffetta, P.: Interactions of tobacco smoking with other causes of lung cancer. In: Samet, J.M. (eds.): Epidemiology of lung cancer. New York. Marcel Dekker (1994) 465-493

Schins, R.P.: Mechanisms of genotoxicity of particles and fibers. Inhal. Toxicol. 14 (2002) 57-78

Schneider, J., Popp, W., Woitowitz, H.-J.: Berufskrankheit Lungenkrebs. Epidemiologische und molekularbiologische Erkenntnisse zur Synkanzerogenese durch arbeitsbedingte und nicht arbeitsbedingte Noxen. Atemwegs.-Lungenkrankh. 23(12) (1997) 708-716

Schneider, J., Erdogan, S., Woitowitz, H.-J.: PAK-assoziierte Lungenkrebserkrankungen. Ein Beitrag zum Problem der synergistischen Synkanzerogenese. Arbeitsmed. Sozialmed. Umweltmed. 34(11) (1999) 476-482

Seidman, H., Selikoff, I.J., Hammond, E.C.: Short term asbestos work exposure and long term Observation. Ann. NNYAcad. Sci. 330 (1979) 61-90

Selikoff, I.J., Hammond, E.C., Seidman, H.: Mortality experience of insulation workers in the United Stated and Canada, 1943-1976. Ann. NY Acad. Sci. 330 (1979) 91-116

Selikoff, I.J., Hammond, E.C., Seidman, H.: Latency of asbestos disease among insulation workers in the United States and Canada. Cancer 46(12) (1980) 2736-2740

Selikoff, I.J., Hammond, E.C., Churg, J.: Asbestos exposure, smoking and neoplasia. J. Am. Med. Assoc. 204(2) (1968) 104-112

Selikoff, I.J., Hammond, E.D.: Multiple risk at high risk of cancer. New York, Academic Press, 1975, 467-483

Simeonova, P.P., Toriumi, W., Kommineni, C., Erkan, M., Munson, A.E., Rom, W.N., Luster, M.I.: Molecular regulation of IL-6 activation by asbestos in lung epithelial cells: role of reactive oxygen species. J. Immunol. 159(8) (1997) 3921-3928

Sincock, A., Seabright, M.: Induction of chromosome changes in Chinese hamster cells by exposure to asbestos fibres. Nature 257(5521) (1975) 56-58

Sincock, A.M.: Preliminary studies of the in vitro cellular effects of asbestos and fine glass dusts. In: Hiatt, H.H., Watson, J.D., Wi'nsten, J.A. (eds.): Origins of human cancer. Cold Spring Harbor, NY, Cold Spring Harbor Laborasory, 1977, 941-954

Spinelli, J.J., Band, P.R., Svirchev, L.M., GaLLgher, R.P.: Mortality and cancer incidence in aluminium reduction plant workers. J. Occup. Med. 33 (1991) 1150-1155

Testa, J.R., Carbone, M., Hirvonen, A., Khalili, B., Krynska, B., Linnainmaa, K., Pooley, F.D., Rizzo, P., Rusch, V., Xiao, G.H.: A multiinstitutional study confirms the presesnce and expression of simian virus 40 in human malignant mesotheliomas. Cancer Res. 58(20) (1998) 4505-4509

Unfried, K., Schürkes, C., Abel, J.: Distinct spectrum of mutations induced by crocidolite asbestos: Clue for 8-hydroxydeoxyguanosinedependent mutagenesis in vivo. Cancer Res. 62 (2002) 99-104

Valerio, F., de Ferrari, M., Ottaggio, L., Repetto, E., Santi, L.: Chromosomal aberrations induced by chrysotile and crocidolite in human lymphocytes in vitro. Mutat. Res. 122(3-4) (1983) 397-402

Vallyathan, V., Shi, X.: The rote of oxygen free radicals in occupational and environmental lung diseases. Environ. Health Perspect. 105 (1997) Suppl. 1, 165-177

Varga, C., Horväth, G., Timbrell, V.: In vivo studies on genotoxicity and cogenotoxicity of ingested UICC anthophyllite asbestos. Cancer Letters 105 (1996a) 181-185

Varga, C., Poscai, Z., Horväth, G., Timbrell, V.: St:udies on genotoxicity of orally administered crocidolite asbestos in rats: Implications for ingested asbestos induced carcinogenesis. Antigancer Research 16 (1996b) 811-814

Varga, C., Horväth, G., Pocsai, Z., Timbrell, V.: On the mechanism of cogenotoxic action between ingested amphibole asbestos fibres and benzo[a]pyrene: I. Urinary and serum mutagenicity studies with rats. Cancer Letters 128 (1998) 165-169

Viegi, G., Prediletto, R., Paoletti, P., Carrozzi, L., Di Pede, F., Vellutini, M., Di Pede, C., Giuntini, C., Lebowitz, M.D.: Respiratory effects of occupational exposure in a general population sample in north Italy. Am. Rev. Respir. Dis. 143(3) (1991) 510-515

Weili, H., Huhges, J.M., Waagenpack, C.: Inmalignancy risk in asbestos cement manufacturing. Am. Rev. Resp. Dis. 120 (1979) 345-354

Wichmann, H.E" Möhner, M., Brüske-Hohlfeld, 1.: Lungenkrebsrisiko durch die berufliche Strahlenexposition in Kombination mit Asbest- und anderen relativen zusätzlichen Expositionen von Uran-Bergarbeitern der WISMUT AG. Gut-

achterliche Stellungnahme im Auftrag der Bergbau-Berufsgenossenschaft GSF-EP S 7/1996

Woitowitz, H.J.: Die Problematik der konkurrierenden Kausalfaktoren. In: Kolloquium Krebserkrankungen und berufliche Tätigkeit (Hrsg.): Südd. Eisen- und Stahl-BG, Berichtsband zum Kolloquium, Mainz 13.07.1988, 37-61

Woitowitz, H.J.: Berufsbedingter Lungenkrebs - offene Fragen: Synkanzerogenese. Arbeitsmed. Sozialmed. Umweltmed. 37(3) (2002) 118-127

Xu, X., Christiani, D.C., Dockery, D.W., Wang, L.: Exposureresponse relationships between occupational exposures and chronic respiratory illness: a communitybased study. Am. Rev. Respir. Dis. 146 (1992) 413-418

Xu, A., Wu, L.J., Santella, R.M., Hei, T.K.: Role of oxyradicals in mutagenicity and DNA damage induced by crocidolite asbestos in mammalian cells. Cancer Res. 59 (1999) 5922-5926

Xue, W., Warshawsky, D.: Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: a review. Toxicol. Appl. Pharmacol. 206(1) (2005) 73-93. Epub 2005 Jan 8.

Yegles, M., Saint-Etienne, L., Renier, A., Janson, X., Jaurand, M.C.: Induction of metaphase and anaphase/telophase abnormalities by asbestos fibres in rat pleural mesothelial cells in vitr. Am. J. Respir. Cell. Mol. Biol. 9(2) (1993) 186-191

Yoshimura, H., Takemoto, K.: Effect of cigarette Smoking and/or N-bis(2-hydroxypropyl)nitros amine (DHPN) on the development of lung and pleural tumors in rats induced by administration of asbestos. Sangyo Igaku 33 (1991) 81-93

Ziem, U., Pott, F.: Prüfung der Kanzerogenität von 16 polyzyklischen aromatischen Kohlenwasserstoffen im Subkutantest bei der Maus. Teil des Abschlussberichtes der Arbeitsgruppe "Untersuchung über die Karzinogene Belastung des Menschen durch Luftverunreinigung" für das Umweltbundesamt, Berlin 1983

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1) Bei der logistischen Regression schätzt man das Odds Ratio, bei der Cox-Regression das Hazard Ratio. Beide Schätzer approximieren das relative Risiko RR. RRAB´ bei nur Noxe A und nicht B und RR

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